Chemical and biochemical aspects of superoxide and superoxide dismutase

Superoxide dismutase Superoxide dismutase

Superoxide-mediated clastogenesis and anticlastogenic effects of exogenous superoxide dismutase.

Superoxide-mediated clastogenesis is characteristic for various chronic inflammatory diseases with autoimmune reactions and probably plays a role in radiation-induced clastogenesis and in the congenital breakage syndromes. It is consistently prevented by exogenous superoxide dismutase (SOD), but not by heat-inactivated SOD, indicating that the anticlastogenic effect is related to the catalytic ...

Superoxide dismutase: master and commander?

I nhaled nitric oxide (NO) has long been known to be an effective pulmonary vasodilator in the normal pulmonary vasculature. In the classical NO signalling pathway, it activates soluble guanylate cyclase in the cytoplasm of pulmonary artery smooth muscle cells, leading to the production of cyclic guanosine monophosphate (cGMP), which then activates protein kinase G (PKG). PKG, acting through se...

Effect of Superoxide Dismutase

This study assesses the effect of the superoxide anion scavenger superoxide dismutase on myocardial capillary permeability-surface area (PS) products for small hydrophilic molecules after ischemia and reperfusion. Open-chest dogs underwent a 20-minute occlusion of the left anterior descending coronary artery followed by 1 hour of reperfusion. Myocardial plasma flow rate and capillary extraction...

Superoxide Dismutase and Sulfite Oxidation

DDTC, SOD, Sulfite Oxidation 50 U SOD in 1 ml or 10 m M DDTC do not much change sulfite oxidation due to the free radicals procuding system xanthin-xanthin oxidase. Sulfite oxidation due to the activity of this free radicals producing system proceeds probably as the univalent oxidation o f sulfite. The role o f SOD in SO, resistance mechanism in plants and the role o f DDTC as S 0 2 oxidation e...